Enantioselective Palladium-Catalyzed Decarboxylative Allylic Alkylations

摘要

Palladium-catalyzed asymmetric allylic alkylation (AAA) has become one of the most efficient ways to construct carbon-carbon bonds with stereocenters.[1] Although a high level of enantioselectivity can be achieved with soft nucleophiles, until recently ketone enolates, which are non-stabilized enolates, have been deemed as poor substrates and have afforded products with low enantioselectivities. It is thought that they attack palladium instead of the -allyl during the reaction. Recently, studies on palladium-catalyzed decarboxylative AAA reactions (Tsuji protocol) have greatly expanded the scope of the nucleophile, in particular, with ketone enolates.