Total Synthesis of Tubulysins U and V

摘要

Tubulysins (Scheme 1) are a family of tetrapeptides produced in rather small quantities (<4 mg L-1 culture broth) by two different species of myxobacteria: Archangium gephyra and Angiococcus disciformis. The structure, stereochemistry, and biosynthetic pathway of the tubulysins were recently determined by H?fle, Reichenbach, and co-workers, who also reported the potent cytotoxicity (in the nanomolar concentration range) of these compounds.