Total Synthesis of Phorboxazole B

摘要

Since their isolation by Molinski and Searle in 1995,the structurally complex phorboxazoles A and B (Scheme 1) have sparked a flurry of interest from the synthetic community.Comprising 15 asymmetric centers,four diversely substituted hydropyran rings,a 21-membered macrolactone,two oxazole rings,and a variety of unsaturations,the phorboxazoles present a considerable challenge.