Intermolecular Hydrogen Bonding Modulates the Hydrogen-Atom-Donating Ability of Hydroquinones

摘要

Hydrogen bonds and redox processes are highly connected in nature:redox enzymes use specific noncovalent interactions to control the redox behavior of organic cofactors such as quinones,flavins,nicotinamides,and pterins.Among these cofactors,quinone and hydroquinone species play a central role in energy transduction,by shuttling electrons between the various components of electron-transport chains.The role of hydrogen bonding in modifying the reduction potential and the reactivity of quinones has been extensively studied by using hydrogen-bond-donating solvents and biomimetic receptors.