Total Synthesis of Microsclerodermin E

摘要

Lithistid sponges are well-known among marine organisms for their ability to produce a diverse array of biologically active metabolites.From several species of the lithistid sponge Microscleroderma sp.and Theonella sp.,Faulkner and co-workers have isolated a series of cyclic peptides named microsclerodermins A-I.