Total Syntheses of Zaragozic Acid

摘要

Who is nowadays not aware of the negative effects on health of high cholesterol levels in blood? Atherosclerosis, hypertension, and myocardiac infarction can be the consequences of this metabolic disturbance (Scheme 1). On the one hand the diet influences the cholesterol level exogenously, on the other hand the body builds up cholesterol endogenously. The biosyn-thetic pathway of cholesterol begins with a branching of the citric acid cycle. Starting from 3-hydroxy-3-methylglutaryl-(HMG)- CoA, farnesyldiphosphate is formed via mevalonate. The coupling of two molecules of farnesyldiphosphate yields squalene, which is then converted into cholesterol.