γ-Substituted Peptide Nucleic Acids Constructed from L-Lysine are a Versatile Scaffold for Multifunctional Display

摘要

Peptide nucleic acids (PNAs), which contain an achiral, uncharged aminoethylglycine (aeg) backbone, bind natural nucleic acids through Watson-Crick base pairing with high affinity and selectivity (Scheme 1 a).[1]-[3] PNA oligomers are not enzymatically degraded,[4] do not require high salt concentration for binding,[2] and are useful in nucleic acid detection systems[5] and as antisense molecules.