Sequence-Specific DNA Binding by Noncovalent Peptide–Tripyrrole Conjugates

摘要

The initiation of gene transcription is dependent on the interaction between specific proteins and short DNA sequences that are usually located upstream of the promoter of the gene.[1] In most cases,these proteins are unable to bind DNA as monomeric modules and need to cooperate with other proteins to form high-affinity complexes with specific DNA sequences.[2] Such is the case for the bZIP family of transcription factors,which bind DNA as leucine-zipper-mediated homo- or heterodimers,with an N-terminal basic region (BR) of each monomer inserting into adjacent DNA major grooves.