Highly Enantioselective Pd-Catalyzed Allylic Alkylations of Acyclic Ketones

摘要

Since the first example of Pd-catalyzed asymmetric allylic alkylation(AAA)was reported by Trost and Strege,great achievements in this area of chemistry have been made.Today,AAA is not only a well-studied transition-metal-catalyzed asymmetric reaction but also one of the most important asymmetric carbon-carbon bond-forming reactions.As a diversity of bond types can be formed and many chiral elements can be installed at the nucleophile,the electrophile,or both,transition-metal-catalyzed AAAs have become a powerful tool in organic synthesis.