Insight into and Practical Application of pH-Controlled Asymmetric Transfer Hydrogenation of Aromatic Ketones in Water

摘要

Catalysis in water represents a major area of intense research in modern chemistry.'11 Water is inexpensive,readily available,and environmentally benign,and is thus an ideal solvent for chemical reactions.We recently reported that asymmetric transfer hydrogenation of aromatic ketones with the Ru-(i?,i?)-Ts-dpen catalyst (Ts-dpen = N-(p-toluenesulfonyl)-l,2-diphenylethylenediamine) or its polymer-supported analogue