An Activatable Polymeric Reporter for Near‐Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer

Li Qing; Li Shenhua; He Shasha; Chen Wan; Cheng Penghui; Zhang Yan; Miao Qingqing; Pu Kanyi

摘要

Abstract >Discriminative detection of invasive and noninvasive breast cancers is crucial for their effective treatment and prognosis. However, activatable probes able to do so in?vivo are rare. Herein, we report an activatable polymeric reporter (P‐Dex) that specifically turns on near‐infrared (NIR) fluorescent and photoacoustic (PA) signals in response to the urokinase‐type plasminogen activator (uPA) overexpressed in invasive breast cancer. P‐Dex has a renal‐clearable dextran backbone that is linked with a NIR dye caged with an uPA‐cleavable peptide substrate. Such a molecular design allows P‐Dex to passively target tumors, activate NIR fluorescence and PA signals to effectively distinguish invasive MDA‐MB‐231 breast cancer from noninvasive MCF‐7 breast cancer, and ultimately undergo renal clearance to minimize the toxicity potential. Thus, this polymeric reporter holds great promise for the early detection of malignant breast cancer. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >侵入性和非侵入性乳腺癌的鉴别检测对于它们有效治疗和预后至关重要。然而，能够这样做的可激活探头？体内很少见。在此，我们报告了一种可活化的聚合物报告（P-DEX），其特异性地打开近红外（NIR）荧光和光声（PA）信号，响应于侵袭性乳腺癌过表达的尿激酶型纤溶酶原激活物（UPA）。 P-DEX具有肾可清除的葡聚糖骨架，其与伴有UPA可切割的肽基材的NIR染料连接。这种分子设计允许P-DEX用于被动靶肿瘤，激活NIR荧光和PA信号，以有效地区分从非侵入性MCF-7乳腺癌的侵袭性MDA-MB-231乳腺癌，并最终经历肾间隙以最小化毒性潜力。因此，这种聚合物记者对早期发现恶性乳腺癌的许可承担良好的希望。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-19011/'>《Angewandte Chemie》</a> <b style="margin: 0 2px;">|</b><span>2020年第18期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Qing&option=202" target="_blank" rel="nofollow">Li Qing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Shenhua&option=202" target="_blank" rel="nofollow">Li Shenhua;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=He Shasha&option=202" target="_blank" rel="nofollow">He Shasha;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Wan&option=202" target="_blank" rel="nofollow">Chen Wan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cheng Penghui&option=202" target="_blank" rel="nofollow">Cheng Penghui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Yan&option=202" target="_blank" rel="nofollow">Zhang Yan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Miao Qingqing&option=202" target="_blank" rel="nofollow">Miao Qingqing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pu Kanyi&option=202" target="_blank" rel="nofollow">Pu Kanyi;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>State Key Laboratory of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSuzhou 215123 China;</p> <p>State Key Laboratory of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSuzhou 215123 China;</p> <p>School of Chemical and Biomedical EngineeringNanyang Technological UniversitySingapore 637457 Singapore;</p> <p>State Key Laboratory of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSuzhou 215123 China;</p> <p>School of Chemical and Biomedical EngineeringNanyang Technological UniversitySingapore 637457 Singapore;</p> <p>National Engineering Research Centre for NanomedicineHuazhong University of Science and Technology1037 Luoyu Road Wuhan 430074 China;</p> <p>State Key Laboratory of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSuzhou 215123 China;</p> <p>School of Chemical and Biomedical EngineeringNanyang Technological UniversitySingapore 637457 Singapore;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1188.html" title="应用化学">应用化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=activatable probe&option=203" rel="nofollow">activatable probe;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cancer&option=203" rel="nofollow">cancer;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=near-infrared fluorescent probes&option=203" rel="nofollow">near-infrared fluorescent probes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=polymers&option=203" rel="nofollow">polymers;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=photoacoustic imaging&option=203" rel="nofollow">photoacoustic imaging;</a> </p> <div class="translation"> 机译：可激活探头;癌症;近红外荧光探针;聚合物;光声成像; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704028160746.html">Cover Picture: An Activatable Polymeric Reporter for Near‐Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer (Angew. 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