Total Synthesis of(+)-Neopeltolide

摘要

Neopeltolide is a marine macrolide that was isolated from a deep-sea sponge of the Neopeltidae family by Wright and coworkers(Scheme 1).The gross structure,including the relative stereochemistry,was determined based on extensive 2D-NMR analysis.Recently,two independent total syntheses of this natural product,from the research groups of Panek and Scheidt,have resulted in the stereochemical reassignment of the originally proposed structure 1 and the unambiguous determination of the absolute stereostructure,as represented by structure 2(Scheme 1).