Role of methionine in nocturnal melatonin peak in the pineal gland.

摘要

Methionine dose-dependently stimulated O-methylation of hydroxyindoles in the pineal gland and contributed to the nocturnal melatonin peak in adult male Wistar rats. Methionine is involved in the maintenance of diurnal rhythms by regulating biochemical transformations of indoles in pinealocytes. Our findings provide theoretical basis for new applications of methionine.