Total Syntheses of (±)-Aspidophylline A

摘要

Aspidophylline A (1) is an indole alkaloid which has been isolated in 2007 from the stem bark of Kopsia singapurensis, a plant of the Apocynaceae family. Aspidophylline A exhibits a complex pentacyclic structure featuring a tricyclic furoindoline motif, five contiguous stereogenic centers incorporated in a highly substituted cyclohexyl ring, and a bridged aza-bicycle (Figure 1). There are three reported total syntheses of the title compound (in its racemic form).