PhI(OAc)2-Mediated Radical Trifluoromethylation of Vinyl Azides with Me3SiCF3

摘要

The fluorine-containing organic motif is becoming privileged in pharmaceuticals, agrochemicals, and functional materials, owing to its unique properties such as electron-withdrawing character, metabolic stability, and lipophilicity. Described herein is the PhI(OAc)2-mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 to efficiently generate a-trifluoromethyl azines. The resulting a-trifluoro-methyl azines were successfully transformed to valuable fluorine-containing molecules such as a-trifluoromethyl ketones, β-trifluoromethyl amines, 5-fluoropyrazoles, and tri-fluoroethyl isoquinolines.