Silver-Catalyzed Oxidative Activation of Benzylic G—H Bonds for the Synthesis of Difluoromethylated Arenes

摘要

A mild and catalytic method to form difluoromethylated arenes through the activation of benzylic C—H bonds has been developed. Utilizing AgNO3 as the catalyst, various arenes with diverse functional groups undergo activa-tion/fluorination of benzylic C—H bonds with commercially available Selectfluor reagent as a source of fluorine in aqueous solution. The reaction is operationally simple and amenable to gram-scale synthesis.