Catalytic Enantioselective Iodoetherification of Oximes

摘要

Heterodifunctionalization of unactivated olefins continues to be an attractive and widely utilized strategy for the generation of densely functionalized organic molecules. Electrophilic halogen induced reactions of olefins are remarkably efficient and popular for olefin heterodifunctionalization, mostly because of the stereoselectivity associated with it. Development of asymmetric versions of these reactions proved challenging despite numerous attempts. However, the last few years have witnessed a tremendous advancement in this area. Since the initial breakthroughs in 2010, numerous examples concerning catalytic asymmetric halolactoniza-tion, haloaminocyclization, haloetherification, and other halofunctionalization reactions of olefins appeared using various activation concepts (Scheme l).