The development of novel and efficient tools for synthesis has been, and still is, closely connected with the synthesis of natural products and bioactive compounds. Firstly, the ever-increasing complexity of the target structures demands more and more selective, milder, and also economical procedures. Secondly, successful applications of these tools in total synthesis are clear evidence of their practicability and effectiveness. In many cases the design, the quality, and thus the elegance of a synthesis are based on the clever implementation of modern synthetic methods.
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