Remodeling Cross-β Nanotube Surfaces with Peptide/Lipid Chimeras

摘要

Peptide/lipid chimeras, which are generally referred to as peptide amphiphiles, array specific peptides on the surface of ordered lipid assemblies.These materials are being explored as tissue scaffolds, in drug delivery, as antimicrobrials, and for biomineralization applications.However, the increasing realization that simple peptides with high cross-β fold propensity can achieve long-range ordered arrays comparable to lipid amphiphiles has now allowed for the creation of an entirely new architectural framework. This framework not only offers precisely controlled positioning of charges and hydrophobic patches along a robust nanotube surface, but also the systematic adjustment of that spacing in a manner that to this point has been unrealized in self-assembling materials.