Protein-Ligand Interactions

摘要

Understanding the principles of protein-ligand interactions is at the heart of rational and computational drug design. This research field involves the medicinal chemistry of small organic molecules, the biophysics of protein structure and dynamics, and the physical chemistry of the surrounding solvent medium. It has therefore become a beautiful interdisciplinary forum for researchers from different experimental and theoretical backgrounds. Even if one focuses exclusively on computational research in this field, this involves researchers with backgrounds in several different disciplines, ranging from computational chemistry to theoretical biophysics and to structural bioinformatics. Many textbooks and more advanced texts have already addressed various facets of this field. An important new contribution is the book Protein-Ligand Interactions, edited by Holger Gohlke of the University of Dusseldorf, which recently appeared as Volume 53 in the Wiley-VCH series Methods and Principles in Medicinal Chemistry.