Free-Energy Landscapes of Ion Movement through a G-Quadruplex DMA Channel

摘要

The folding of guanine(G)-rich DNA and RNA sequences into high-ordered G-quadruplex structures is known to depend critically on the presence of monovalent ions such as Na~+, K~+, and NH4~+. Although G-quadruplex DNA and RNA structures can display a diverse range of topologies, they all contain a very similar central core structure consisting of multiple G-quartets that are stacked on top of one another to form a channel-like pore.