Enantioselective Construction of Pyrroloindolines Catalyzed by Chiral Phosphoric Acids: Total Synthesis of (-)-Debromoflustramine B

摘要

Pyrroloindolines are an important class of alkaloids found in an array of natural products. As shown in Figure 1, various substitutions on the indoline ring, especially at the C3 position, give rise to fascinating and biologically important structures. The biological activities of these compounds have been well studied, the results of which have shown several promising applications, including muscle relaxants, potassium channel-blockers,and anti-cancer agents.