Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor

摘要

The aryl fluoride motif is a mainstay in a variety of disciplines, most notably pharmaceuticals, agrochemicals, and in positron emission tomography (PET). A large number of clinically approved pharmaceuticals contain this substituent due to its importance in tailoring the properties of organic molecules.'11 While numerous methods have been developed to construct aromatic C—F bonds, most, if not all, suffer from at least one drawback with regard to safety, practicality, and/or substrate scope.