Enantioselective Rhodium(I)-Catalyzed [3+2] Annulations of Aromatic Ketimines Induced by Directed C-H Activations

摘要

Directed functionalizations of unactivated arene C-H bonds with transition-metal catalysts have evolved to be a highly prosperous field in organic chemistry, and enable a complementary and highly efficient access to a broad variety of building blocks. Most often, the directing group itself remains intact during the reaction and needs to be cleaved or modified accordingly in follow-up steps. In this respect, a modification or direct incorporation of this group in the C-H functionalization reaction is an attractive strategy that induces additional complexity.