One-Pot Synthesis of a-Amino Acids from Imines through CO2 Incorporation: An Alternative Method for Strecker Synthesis

摘要

Carbon dioxide is an abundant and inexpensive carbon source (C1 unit); however, its inertness and gaseous character sometimes hamper its use for efficient C—C bond-forming reactions in organic synthesis. To overcome this problem, strongly nucleophilic organometallic regents, such as RLi and RMgX, are often used for C-C bond construction that incorporates CO2. Recently, transition-metal-promoted CO2 fixation reactions, especially those involving metal-activated/attached unsaturated bonds, have been reported. However, there have been relatively few examples of robust C—C bond-forming reactions between CO2 and an sp~3-hybridized carbon center under mild reaction conditions.