Intermolecular N-Heterocyclic Carbene Catalyzed Hydroacylation of Arynes

摘要

Arynes are highly reactive intermediates endowed with numerous applications in organic synthesis. The introduction of 2-(trimethylsilyl)aryl triflates as mild arync precursors led to a rapid growth of this field. Arynes have been utilized extensively in transition-metal-catalyzcd reactions and, recently, efforts have been devoted to transition-metal-free reactions, which include the initial addition of nucleophiles to arynes and subsequent trapping with electrophiles.