Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry

摘要

Mass spectrometry (MS) is a powerful tool for the analysis of complex mixtures, providing information on the molecular weights and chemical structures of the analytes. Solutions are normally ionized using electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI), while solids are often ionized using matrix-assisted laser desorption ionization (MALDI). Complex mixtures are routinely separated using chromatography before the MS measurement in order to minimize suppression effects on analyte ionization and to preconcentrate the analytes. Ambient ionization methods, including desorption electrospray ionization (DESI), direct analysis in real time (DART), and others, have recently been developed to address the need for rapid methods of direct analysis of complex mixtures without sample preparation. Qualitative and semiquantitative analysis has been achieved using these experiments which typically take only a few seconds.