A Synthetic Vaccine Consisting of a Tumor-Associated SiaryI-T_N-MUC1 Tandem-Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly Selective Immune Response

摘要

The development of an antitumor vaccine has to meet three important criteria: The induced immune response has to be strong enough to override the tolerance against tumor associated self antigens such as glycolipids and glycoproteins, which are structures present on normal cells ; the presented antigen must be tumor specific, strongly expressed, and different from related structures on normal cells; and the immune response must result in the formation of highly selective antisera, so that an autoimmune reaction against healthy tissue is not triggered. The membrane-bound tumor-associated glycoprotein MUC1 could meet these last two criteria. It is expressed on almost all epithelial tissues and highly overexpressed on tumor tissue.