Palladium-Catalyzed Three-Component Cascade Cyclization Reaction of Bisallenes with Propargylic Carbonates and Organoboronic Acids: Efficient Construction of cis-Fused Bicyclo[4.3.0]nonenes

摘要

The palladium-catalyzed coupling reaction involving propargylic/allenic metallic reagents provides one of the most straightforward pathways for the formation of allenes. In this area, we have noticed that the palladium-catalyzed coupling reaction of propargylic carbonates with boronic acids or organozinc reagents affords alkynes or allenes depending on the steric hindrance of the starting materials. Moreover, multicomponent cascade reactions (MCRs) are among the most efficient synthetic methods for the construction of complex organic molecules.