All Kinds of Reactivity: Recent Breakthroughs in Metal-Catalyzed Alkyne Chemistry

摘要

Recent developments in transition-metal-catalyzed processes with alkyne substrates have enabled the synthesis of a plethora of diverse products. Simple terminal alkynes are often used to prepare more elaborate disubstituted derivatives through metal-promoted reactions. Early examples include the Glaser-Hay oxidative dimerization of alkynesand the Sonogashira coupling reaction. Another milestone was the catalytic asymmetric alkynylation of aldehydes developed by Carreira and co-workers to furnish highly enantioenriched propargylic alcohols.Two very recent advances have broadened the range of alkynes that are readily accessible by C-N and C-C bond-forming reactions.