Sequencing Single DNA Molecules in Real Time

摘要

The market for fast and inexpensive DNA sequencing technology has never been larger than today. It comprises research interests like comparative genomics, evolution, and epidemiology studies as well as forensic examinations and the large sector of medical diagnostics. Above all, identification of human DNA sequence variation promises a key to understanding health and disease. The strong interest in these biomedical problems has triggered the development of diverse techniques for single-nucleotide polymorphism (SNP) genotyping or DNA sequencing in real-time and with the potential to be massively scaled up.