Kinetic Resolution of Quaternary and Tertiary β-Hydroxy Esters

摘要

Despite remarkable advances in enantioselective synthesis, the preparation of single enantiomer quaternary stereocen-ters remains a challenging and important goal in organic chemistry. The difficulties associated with the use of ketone electrophiles is illustrative, where attenuated reactivity, challenging carbonyl enantiofacial differentiation, and diminished stability to retroaldol decomposition can explain, in part, the wealth of techniques for enantioselective aldol additions to aldehydes compared to ketones. In such instances, kinetic resolution of a racemic product may be an attractive alternative to enantioselective synthesis and remains an important method of accessing enantiopure material.