Solvent-Free Synthesis of Peptides

摘要

The chemistry of peptides has been continuously growing during the last few decades. Peptides are now not only considered as pharmacological tools but also as active pharmaceutical ingredients, in connection to their high therapeutic index and low toxicity. The market for therapeutic bulk peptides is expected to grow rapidly in the next few years. In spite of the well-established procedures for peptide synthesis by chemical ways, that is, stepwise synthesis in solution and solid-phase peptide synthesis, one of the major problems related to peptide preparation concerns the huge amount of solvent needed, particularly for synthesis on solid supports (2000-5000 kg for a large peptide). There is still a need to explore efficient, convenient, and environmentally friendly methods for peptide synthesis, particularly when the time for the scale-up of peptide production comes.