Intermolecular Double Prins-Type Cyclization:A Facile and Efficient Synthesis of 1,6-Dioxecanes

摘要

Medium-sized oxygen heterocyclic ring systems,particularly those with ten members,are a common structural feature of numerous natural products as well as functionalized organic molecules.Owing to unfavorable entropic and enthalpic factors,synthetic routes towards such compounds have been difficult to study and as a result,the development of a practical and convenient process to create rings of this size still remains a major synthetic challenge.