Bmaphthyl-DNA: Stacking and Fluorescence of a Nonplanar Aromatic Base Surrogate in DNA

摘要

The replacement of canonical nucleobases with artificial aromatic surrogates allows the incorporation of new functions into the base stack of DNA. Arenes and heteroarenes have been introduced as shape mimics of natural bases and as artificial base pairs to help understand DNA-DNA and DNA-protein interactions. Many base surrogates exhibit interesting fluorescence properties, which depend on stacking interactions with the environment. This has allowed the design of probes that report on the structure and function of enzymes and nucleic acids. Recently, it has been recognized that oligomeric assemblies of fluorescent base surrogates offer the interesting opportunity to tune the optical properties through hybridization-controlled dye-dye interactions.