Chiral gamma-Amino Amide Synthesis by Heterobimetallic Lanthanum/Lithium/Pybox-Catalyzed Direct Asymmetric Mannich-Type Reactions of alpha-Keto Anilides

摘要

Many excellent direct catalytic enantio-and diastereoselec-tive Mannich(-type)reactions have been reported during the past decade,providing versatile synthetic methods for optically active beta-amino acids and related compounds.In contrast,catalytic enantioselective methods leading to chiral gamma-amino acids or their equivalents are limited,despite their importance as key structural motifs in natural products and in many pharmaceuticals,such as clinically used modulators of neurotransmission.