Mesoporous Silica Nanosphere Supported Ruthenium Catalysts for Asymmetric Hydrogenation

摘要

Asymmetric catalysis is a powerful method for the synthesis of pharmaceutically important chiral molecules. Numerous highly selective chiral catalysts have been developed recently, but their practical applications in industrial processes are often hindered by their high costs as well as difficulties in removing trace amounts of toxic metals from the organic products. Many different approaches have been developed to immobilize homogeneous asymmetric catalysts in order to overcome these problems, with the covalent attachment of chiral catalysts to mesoporous silica materials being one of the most promising methods for generating heterogenized asymmetric catalysts. MCM- and SBA-type silicas provide ideal supports for asymmetric catalyst immobilization owing to their ordered structures, very high surface areas, and uniform, large, and tunable pore diameters.