Structure of the Tyrosyl Biradical in Mouse R2 Ribonucleotide Reductase from High-Field PELDOR

摘要

Ribonucleotide reductase (RNR) is a target enzyme for cancer chemotherapy and antiviral agents.Structural studies of RNR from different organisms can provide fundamental information to develop new drugs.In this respect,the mammalian mouse RNR serves as a model for human RNR.Almost all eukaryotic organisms encode class I RNRs and are composed of two subunits,R1 and R2.