Enantioselective Synthesis of Allylsilanes Bearing Tertiary and Quaternary Si-Substituted Carbons through Cu-Catalyzed Allylic Alkylations with Alkylzinc and Arylzinc Reagents

摘要

Allylsilanes are widely used in stereoselective organic synthesis.Design and development of efficient catalytic asymmetric methods that furnish chiral allylsilanes in high enantiomeric purity would significantly expand the utility of these versatile nucleophiles.Herein,we report an efficient method for enantioselective synthesis of a range of allylsilanes by Cu-catalyzed asymmetric allylic alkylation (AAA) of Si-substituted unsaturated phosphates with dialkyl- and diarylzinc reagents [Eq.(1)].