Immuno-Polymeric Nanoparticles by Diels-Alder Chemistry

摘要

Immunonanoparticles hold great promise for targeted delivery of drugs,therapeutics,and diagnostics as numerous possible target receptors have been identified on the surface of cells in pathological conditions.Under in vivo conditions,immuno-nanoparticles can deliver these agents to specific sites by both passive targeting,where a hydrophilic polymer outer layer such as polyethylene glycol(PEG)leads to longer circulation in the blood stream,and active targeting mechanisms,where the"passive"nanoparticles have antibody molecules or fragments covalently coupled to their surface to achieve localized delivery to target cells that express the corresponding antigen receptors.