Solution-Phase Mixture Synthesis with Double-Separation Tagging:Double Demixing of a Single Mixture Provides a Stereoisomer Library of 16 Individual Murisolins

摘要

Most small organic molecules are synthesized individually,but there is a compelling reason to synthesize molecules as mixtures-The effort conserved in a synthesis is directly proportional to the number of compounds that are mixed."Split/mix" methods conduct reactions on mixtures of beads yet provide individual products at the end.Recently,a general concept for solution-phase mixture synthesis by separation tagging has been introduced and put into practice with homologous fluorous tags.