In an analysis of markers for colon cancer, Anne Lomholt (Hvidovre University Hospital, Denmark) and co-workers followed up 654 patients who had elective surgery until cancer-specific death. After follow-up of 7.9 years, 308 patients had died from colorectal cancer. Univariate analyses showed that PAH (plasminogen activator inhibitor 1), urokinase plasminogen activator receptor, tissue inhibitor of matrix metalloproteinase 1 (TIMP1), tetranectin, YKL-40, vascular endothelial growth factor, mannan-binding lectin serine protease (MASP2), carcinoembryonic antigen, and C-reactive protein were significant predictors of death from colorectal cancer. Multivariate analysis showed that TIMP1, PAH, MASP2, and C-reactive protein predicted such death independent of tumour localisation. Dukes stage, sex, and age.
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