Requirment for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila

摘要

Components of microbial cell walls are potent activators of innate immune re- sponses in animals. For example, the mammalian TLR4 signaling pathway is acti- vated by bacterial lipoplysaccharide and is required for resistance to infection by Gram-negative bacteria. Other components of microbial surfaces, such as pepti- Doglycan, are also potent activators of innate immune responses, but less is known About how those components activate host defense. Here we show that a pep- Tidoglycan recognition protein, PGRP-LC, is absolutely required for the induc- Tion of antibacterial peptide genes in response to infection in Drosophila and Acts by controlling activation of the NF-kB family transcription factor Relish.