Dietary Restriction in Long-Lived Dwarf Flies

摘要

Interventions that slow down aging provide invaluable insights into its causes. But do they act upon common underlying mecha- nisms? Recent work with a long-lived mutant mouse, the Ames dwarf, showed that its lef- span could be further extended by another intervention, dietary restriction, in which food intake was restricted to about 70/100 of voluntary levels (1). This finding was taken to demonstrate that the Ames mutation and dietary restriction slow aging by dif- ferent mechanisms, because the Ames mutation and dietary restriction do not mask each other's effect on life-span.