Adaptive Immune response of Vγ2Vδ2+ T Cells During Mycobacterial Infections

摘要

To examine the role of T cell receptor (TCR) in γδ T cells in adaptive immunity, a macaque model was used to follow Vγ2Vδ2~+ T Cell responses to mycobac- terial infections. These phosphoantigen-specific γδ T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guerin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vγ2Vδ2~+ T cells were also seen during Mycobacterium tuber- culosis infection of naive and BCG-vaccinated macaques, respectively.