Self-Assembled Magnetic matrices for DNA separation Chips

摘要

When a constant, homogeneous magnetic filed is applied to a suspension of superparamagnetic particles confined in a tin gap perpendicular to the field, the particles self-organize into a fixed, quasi-regular array of columns (Fig. 1A) (1). The array returns to a liquid suspension imme- Diately upon field switch-of. The column spac- In can be tuned from submicrometer to about 100 um, by varying cell size and particle con- centration. The pore size is reproducible within better than 5/100 and independent of the strength of the magnetic field, so long as it can hold the array in place during separa- tion (typically > 10 mT, which is achievable with ordinary permanent magnets).