Exploiting Proteomics in the Discovery of Drugs That Target Oxidative Damage

摘要

By the measure of popular cul-ture, one might conclude that antioxidants for the treatment of aging and age-related diseases was settled science. One has only to turn on the television, surf the web, or flip through the pages of most magazines to encounter any number of advertisements with claims that antioxidants will slow or even reverse aging. What's missing, of course, is a significant body of rigorous clinical studies to support the claims that antioxidants are protective against age-related diseases or can increase life span to a significant extent. What new developments might propel the science of antioxidant drug therapy to a more serious level of inquiry? The rapid advance of proteomic methodologies and their application to large-scale studies of protein-protein interactions and protein expression profiles (1, 2) suggest that these methods are well suited to provide the molecular details needed to fully understand oxidative injury.