Reversing Autism in Mice

摘要

Autism comprises a heterogeneous group of neurodevelopmental disorders characterized by defects in communication and social interaction. A group of nonsyndromic forms of autism is associated with mutations in the neuroligin genes, which encode postsynaptic adhesion molecules. Using a reversible knockout approach, Baudouin et al. (p. 128, published online 13 September) investigated the in vivo functions of neuroligin-3 in the mouse cerebellum.