Fried to a CRISPR

摘要

The CRISPR-Cas system, found in many bacteria and archea, is known as an adaptive defense against the invasion of foreign DNA. The bacteria/archea capture fragments of plasmids and phages and incorporate them into one or more CRIPSR loci. The captured sequences are then transcribed and cleaved into short CRISPR (cr)RNAs, which, when bound by a Cas nuclease complex, are used to target the invading nucleic acid for destruction.