Systems Vaccinology

摘要

Vaccination is a powerful approach for disease prevention, but why are some vaccines so effective whereas others fail? Obermoser et al. begin to answer this question by characterizing the immune response induced in people given either the trivalent seasonal influenza vaccine or the pneumococcal vaccine, both of which induce a protective antibody response. Gene expression profiling combined with functional assays at multiple time points after vaccination revealed that the two vaccines take different routes early, despite a similar ability to induce protective antibodies.